Advancing methods for biomolecular crystallography | Perpustakaan Universitas Negeri Jakarta

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Advancing methods for biomolecular crystallography

Read, Randy - Nama Orang; Urzhumtsev, Alexandre G. - Nama Orang; Lunin, Vladimir Y. - Nama Orang;

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.

Karya ini menyajikan potret keadaan terkini kristalografi biomolekuler modern, dari kristalisasi hingga penentuan struktur dan bahkan presentasi interaktif di web. Metode yang mendorong jalur penentuan struktur otomatis terkini dijelaskan, serta cara menangani masalah seperti patologi kristal yang masih memerlukan analisis ahli. Metode-metode ini diilustrasikan melalui penerapannya pada masalah-masalah yang sangat menarik secara biologis, seperti mesin molekuler yang mendasari jalur komplemen, mekanisme kerja penghambat monoamine oksidase, dan struktur ribosom eukariotik. Pendekatan komplementer, seperti difraksi neutron, hamburan sinar-X sudut kecil, difraksi koheren, dan pemodelan komputasional, juga dieksplorasi.

Ketersediaan

Perpustakaan Pusat E394

E394

Tersedia

Informasi Detail

Judul Seri: NATO science for peace and security series A: chemistry and biology
No. Panggil: E394
Penerbit: Dordrecht, Holland : Springer Dordrecht., 2013
Deskripsi Fisik: XIII, 362 Hlm.
Bahasa: English
ISBN/ISSN: 9789400762329
Klasifikasi: NONE
Tipe Isi: text
Tipe Media: computer
Tipe Pembawa: online resource
Edisi: 1
Subjek: Kimia Organik
Protein - Struktur
Spektrometri
Info Detail Spesifik: -
Pernyataan Tanggungjawab: Randy Read, Alexandre G. Urzhumtsev, Vladimir Y. Lunin

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Advancing methods for biomolecular crystallography
https://doi.org/10.1007/978-94-007-6232-9

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